Abstract
The organizers of this symposium felt that it could be helpful if the first paper provided a general introduction to the concepts and techniques associated with this rapidly developing area of biology. It is widely but wrongly believed to be a complex and difficult subject. The details of some of the manipulations are sometimes extremely complex, but the general principles are not. Of those responsible for this paper, Andrew Simpson and Tina Walker are active workers in the field, but Roland Terry is not. Following the principle embodied in an old Arabic proverb (Fig. 1), roughly translated as ‘What one fool can understand, another can’, Roland Terry presented the paper.
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