Abstract
Abstract Extract In order to act and produce effects, unless it acts topically at the site of action, a drug must be absorbed into the blood. The rate of absorption depends upon the route, of administration and physicochemical characteristics of the drug. The physicochemical properties that affect the absorption of a compound are lipid and water solubility, degree of ionization, chemical stability of the drug and molecular weight. A substance will probably be well absorbed if it is lipid-soluble and at the same time also soluble to some extent in water, if it is not completely ionized, and, finally, if its molecular weight is not excessively high (Keberle, 1971 Keberle, H. 1971. Physico-chemical factors of drugsaffecting absorption, distribution and excretion. Acta Pharmac. Tox., 29(suppl. 3): 3047–3047. [Google Scholar]).
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