Abstract
Phagocytosis is usually defined as the cellular process by which cells internalise particulate matter larger than about 0.5μm in diameter. It is an endocytic process, distinct from pinocytosis and macropinocytosis. These latter processes may internalise small particles suspended the extracellular fluid, but this is a by-product of internalising the fluid, and is not phagocytosis per se. In contrast, phagocytosis is targeted at solid particulates, usually microbes, which are internalised and "digested" either to provide food, or as part of the immune system of higher animals. The mechanism of phagocytosis may have, at its core, many primitive elements, but it is a highly complex and coordinated series of cell biological and molecular events which together result in the uptake of a particle. In this introduction, the basis of phagocytosis and some ideas of its origin are discussed.
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