Abstract
In recent years, metabolic flux analysis has become one of the major tools in metabolic engineering (1, 2, 3). The aim of MFA is the detailed quantification of all metabolic fluxes in the central metabolic pathways of a microorganism. The result is a flux map that shows the distribution of anabolic and catabolic fluxes over the metabolic network. Figure 1 shows such a flux distribution for the simple example discussed throughout the text. More complex examples for quite different microorganisms can be found in (4, 5, 6, 7, 8, 9). Based on such a flux analysis, the result of a genetic manipulation can be judged or possible targets for future genetic modifications might be identified. Thus MFA is also an important tool for genetic engineering.
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