An intramolecular 1,3-dipolar cycloaddition approach to a pyrimidoazepinone derivative. A potentially useful intermediate towards the synthesis of pyrimidoazepine based folic acid derivatives

Abstract

An intramolecular nitrile oxide cycloaddition route to the isoxazolinopyrimidoazepine derivative 21 is described. This was transformed to the pyrimidoazepinone derivative 22, a potentially useful intermediate for the synthesis of pyrimidoazepine based folic acid derivatives. [Display omitted]