Abstract
Purpose: Quantitative MRI techniques that assess changes in cartilage structure (morphometry) and composition (T2 relaxometry) have been widely applied in OA research, particularly in the Osteoarthritis Initiative (OAI). However, in the OAI, the double-echo steady-state (DESS) and the multi-echo spin-echo MRI sequences to study morphometry and T2 transverse relaxation times respectively, required 21 minutes of scan time per knee, and all scanning was performed on MRI scanners from only a single vendor.
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