Abstract
AbstractAs one of the fastest‐growing neurological disorders, Parkinson's disease is a neurodegenerative, cardinally motor ailment. Associated with the late onset of symptoms and often misdiagnosed, it inflicts massive life handicaps. To aid in its early detection, the research community is seeking alternative in‐vivo biomarkers, mainly in the field of neuroimaging. This study aimed to build a computer‐aided diagnosis system to distinguish between healthy controls (HC) and early Parkinsonian patients (PD). Our classification paradigm encompasses a Convolutional Neural Network built from scratch to extract discriminatory features, followed by a Bayesian‐optimized Random Forest classifier (CNN_RF). We trained and validated our customized model on the MRI images of 178 PD and 124 HC, taken from the benchmark Parkinson's Progression Markers Initiative (PPMI) dataset, as well as their brain tissue segments and Jacobian determinant maps. The classification was evaluated using seven performance metrics. For visual interpretation, we employed Grad‐CAM to generate saliency maps. Our findings demonstrate the robustness of the proposed method, as it outperformed deep‐tuned ResNet18, VGG16, and SqueezeNet, implemented for comparison. Furthermore, it resulted in 98.9% accuracy, 98.6% specificity, 99.0% precision, 99.5% F1‐score, a 97.7% Matthews correlation coefficient (MCC), and an AUC of 99.6% for the classification of fused gray matter and Jacobian map features. This indicates that the tailored CNN_RF possesses superior adaptability to identify intrinsic characteristics linked to the disease, as highlighted in the salient maps showcasing pertinent regions in the striatum, thalamus, frontal, temporal, and insular cortices for Parkinson's disease classification. Moreover, it offers a single modality and cost‐effective CAD, which could pave the way for a feasible early PD diagnosis. As data availability and AI robustness increase, PD diagnosis will no longer be a challenging task in the future.
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