An interaction effect between glucokinase gene variation and carbohydrate intakes modulate the plasma triglyceride response to a fish oil supplementation (818.3)

Abstract

A large inter‐individual variability in the plasma triglyceride (TG) response to fish oil consumption has been observed. A single‐nucleotide polymorphism (SNP) within glucokinase (GCK) gene has been associated with TG concentrations. Objective: To investigate the gene‐diet interaction effects between SNPs within GCK gene and dietary carbohydrate intakes on the plasma TG response to a fish oil supplementation. Methods: Two hundred and eight participants were recruited in the greater Quebec City area and completed a 6‐week fish oil supplementation (5g fish oil/day: 1.9‐2.2g EPA and 1.1g DHA). Thirteen SNPs within GCK gene were genotyped using TAQMAN methodology. Results: A gene‐diet interaction effect on the plasma TG response was observed between rs741038 and carbohydrate intake when age, sex and BMI were included in the model (p=0.008). In order to compare the plasma TG response between genotypes, participants were divided according to median carbohydrate intakes. Homozygotes of the minor C allele of rs741038 with carbohydrate intakes >48.6% had a greater decrease in their plasma TG concentrations than homozygotes C/C with carbohydrate intakes 蠄48.6% (p=0.002) and also than the other genotypes either with high or low CARB. Conclusion: The plasma TG response to a fish oil supplementation may be modulated by gene‐diet interaction effects involving GCK gene and carbohydrate intakes.Grant Funding Source: Supported by CIHR ‐ (MOP229488)