Abstract

Conventional clinical diagnostic methods are generally based on a single classifier. In present paper, we propose a hybrid Backpropagation neural network (BPNN) classifier based particle swarm optimization (PSO) method. In the present paper by combining the principles two algorithm, we propose a new but simple hybrid algorithm called BPNN_ PSO. Our novel algorithm optimizes BPNN with PSO and reduces computational time of the training phase of BPNN. The performance of the algorithm has been tested with prostate cancer. A total of 360 medical records collected from the patients suffering from neoplasia diseases have been used to train and test the proposed algorithm. The results show that the proposed BPNN–PSO algorithm can achieve very high diagnosis accuracy (98%) and it proving its usefulness in supporting of clinical decision process of prostate cancer. Comparing the simulated results of the above two cases, training the neural network by PSO technique gives more accurate (in terms of sum square error) and also faster (in terms of number of iterations and simulation time) results than BPNN. By using these hybrid method for building machine learning classifiers, we can significantly improve diagnostic performance with respect to the results of clinical practice

Highlights

  • Prostate Cancer (PC) is the most commonly diagnosed nonskin cancer and the second leading cause of cancer deaths in western countries

  • Prostate cancer is a disease in which cancer develops in the prostate, a gland in the male reproductive system

  • Prostate cancer is a disease that can be diagnosed with prostate biopsy in accordance with the suspicions that arose as a result of Prostate-Specific Antigen (PSA) test, rectal examination, and transrectal findings

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Summary

Introduction

Prostate Cancer (PC) is the most commonly diagnosed nonskin cancer and the second leading cause of cancer deaths in western countries. Cancer occurs when cells of the prostate mutate and begin to multiply out of control. Prostate cancer is a disease that can be diagnosed with prostate biopsy in accordance with the suspicions that arose as a result of Prostate-Specific Antigen (PSA) test, rectal examination, and transrectal findings. Despite the need for biopsy for conclusive diagnosis, patients with low cancer risk may avoid this process, which is not without risks due to possible complications that may arise. This is an invasive procedure with the risk of rectal mucosa being damaged, and its high costs. Artificial Neural Networks (ANN), which is one of the artificial intelligence methods, is widely used in the classification of cancer because of the speed in responding to the analyses of marker effect [2,5,7]

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