Abstract
Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. Therefore, the present study analyzed the potential oncogenic role of COPB2 using TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) datasets. The majority of the cancer types overexpressed the COPB2 protein, and its expression significantly correlated with tumor prognosis. In certain tumors, such as those found in breast and ovarian tissues, phosphorylated S859 exhibited high expression. It was found that mutations of the COPB2 protein in kidney and endometrial cancers exhibited a significant impact on patient prognosis. It is interesting to note that COPB2 expression correlated with the number of cancer-associated fibroblasts in certain tumors, such as cervical and endocervical cancers and colon adenocarcinomas. In addition, COPB2 was involved in the transport of substances and correlated with chemotherapy sensitivity. This is considered the first pan-tumor study, which provided a relatively comprehensive understanding of the mechanism by which COPB2 promotes cancer growth.
Highlights
Cancer is the leading cause of death in various countries worldwide, and it is an essential obstacle to increased life expectancy
The expression pattern of complex subunit beta 2 (COPB2) was analyzed in different cancer types derived from TCGA database by the TIMER method
Cancer-associated fibroblasts (CAFs) are often considered to exert protumorigenic properties. Based on these three algorithms (EPIC, MCPCOUNTER, and TIDE), the analysis indicated that COPB2 expression and cancerassociated fibroblasts (CAFs)
Summary
Cancer is the leading cause of death in various countries worldwide, and it is an essential obstacle to increased life expectancy. With the improvement of the public databases, such as TCGA and GEO, it becomes possible to explore the correlation between genes and clinical prognosis and their related signaling pathways through pan-cancer expression analysis of specific genes [2,3,4]. TCGA and the GEO databases were used to extract information from different tumors, which was used to conduct a pan-cancer analysis. The coatomer protein complex subunit beta 2 (COPB2) is encoded by a gene on chromosome 3q23 It is one of the non-clathrin-coated vesicular coat subunits that form the coatomer and play a role in membrane transport between the endoplasmic reticulum and Golgi apparatus. Increasing evidence has recently shown that COPB2 plays an important role in tumorigenesis. COPB2 promotes cell proliferation in vitro and tumorigenesis in vivo by inducing nuclear translocation of YAP1 in lung cancer cells [12]
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