Abstract
Background: Senescent cells are characterized by an arrest in proliferation. In addition to replicative senescence resulting from telomere exhaustion, sub-lethal genotoxic stress resulting from DNA damage, oncogene activation or mitochondrial dysfunction also elicits a senescence phenotype. Methods: Senescence was induced in an osteocarcinoma cancer cell line in response to sub-lethal doses of a genotoxic chemotherapeutic agent, followed by quantitative SWATH proteomics and RNA-seq analyses. Results: We present here an integrative multi-omic analysis of proteomic and RNA-seq from proliferating and senescent osteosarcoma cells. Senescence is a controlled program affecting a wide variety of biological processes with some core hallmarks of senescence as well as cell type specific changes. Conclusions: This study presents an integrated analysis and makes available both RNA-seq and proteomic data from proliferating and senescent cells in appropriate FAIR data repositories to aid reuse by the community.
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