Abstract
BackgroundThere is evidence regarding the usefulness of psychosocial intervention to improve health related quality of life (HRQOL) in adult cancer patients. The aim of this report is to describe an integrated approach and to evaluate its feasibility in routine clinical practice in 98 advanced colorectal cancer (ACC) patients during chronomodulated chemotherapy.MethodsA prospective non-randomised design was developed and applied in a cancer out-patient setting. The intervention consisted of an integrated approach, whereby the psycho-oncologist had an active role in the health care team with the physician and routinely included psychological understanding in the medical treatment program. The psychological evaluation assessed: a) adaptation, awareness, psychopathological disorders through a psychodynamic interview; b) anxiety and depression using the HAD scale; c) subjective perception of care quality through a structured interview and d) HRQOL evaluation assessment with the EORTC QLQ C30. Outcomes data were collected before and after 18 weeks of chemotherapy.ResultsAfter 18 weeks of chemotherapy a significant improvement of adaptation and awareness was observed. The HADs results showed a significant decrease in anxiety when compared to pre-treatment. The structured interview showed a significant increase of patients who positively experienced the impact of medical treatment on HRQOL, anxiety, depression, interpersonal relationships, free-time and who positively experienced the care quality. Indeed, a majority of patients positively experienced the team relationship modality during the whole treatment. All scales on the EORTC questionnaire remained unchanged during the entire treatment.ConclusionOur results suggest that it is feasible to carry out an integrated approach during chemotherapy. These results seem to support the integrated approach as a tool in aiding advanced colorectal cancer patients' ability to cope with their diagnosis and treatment although an appropriately designed study is required to confirm this.
Highlights
There is evidence regarding the usefulness of psychosocial intervention to improve health related quality of life (HRQOL) in adult cancer patients
The objective of this paper was to describe this integrated approach and to evaluate its feasibility in routine clinical practice in advanced colorectal cancer (ACC) patients submitted to chronomodulated chemotherapy
During a five years period, 119 metastatic or locally ACC patients were enrolled in the study
Summary
There is evidence regarding the usefulness of psychosocial intervention to improve health related quality of life (HRQOL) in adult cancer patients. The cancer experience consists of predictable events which, generally, are described on the disease continuum [1]. These events begin with the diagnosis, followed by treatment, remission, recurrence or progression, and the terminal phase. Whether it is surgery, chemotherapy, or radiation therapy, is perceived as a crisis which consists of both the difficulty of integrating cancer diagnosis into a patient's life and the necessary adjustments to the different phases of the disease and treatment. Controlled experimental trials have been more frequently carried out with the former Most of these studies showed a significant improvement in psychiatric symptoms or social adjustment as reported by Greer and Moorey [1618]
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