Abstract
Since last couple of years Self-emulsifying drug delivery systems are becoming important tool in novel drug delivery. It is very useful in solving problems such as low bioavailability issues associated with poorly water soluble drugs. The bioavailability of lipophilic drugs (BCS-II and IV) can be enhanced by these systems. SEDDS is released in the lumen of the gastrointestinal tract (GIT) after administration and with the aid of GI fluid a fine emulsion (micro-/nanoemulsion) is formed. The increased surface area and amphoteric nature of SEDDS lead to increase in bioavailability. The hepatic first-pass effect can be bypassed by these systems because the drugs can subsequently be absorbed by lymphatic pathways. In this review we present a report on the formulation, characterization and dosage forms and applications of selfemulsifying formulations, with examples of currently marketed preparations.
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