An insight into the structure-activity relationship studies of anticancer medicinal attributes of 7-azaindole derivatives: a review.

Abstract

In the current portfolio, there is a lot of interest in the 7-azaindole building block for drug discovery. The creation of synthetic, sophisticated methods for the modification of 7-azaindoles is a promising area of research. This review covers the structure-activity relationship of 7-azaindole analogs, which have been shown to beeffective anticancer agents in the literature of the past twodecades. Positions 1, 3and 5 of the 7-azaindole ring arethe most active sites. Disubstitution is used for the synthesis of a new analog of the 7-azaindole moiety. All positions are used to create novel molecules that areeffective anticancer agents. The alkyl, aryl carboxamide group and heterocyclic ring are the most successful types of substitution.