An insight into new world health organization classification (2022) of odontogenic lesions

Abstract

In March 2022, 5th Edition of the World Health Organization (WHO) Classification of Head and Neck Tumors was released with an online access. Rapid updates of molecular basis of pathologies and quick progression in the field of diagnostic pathology, this time the 5th Edition of classification was released in <5 years of time-span, from its previous classification, which was released in 2017. Although concept behind these two subsequent classifications are not much different from each other, but this is the first time, when essential and desirable criteria are decided for pathologies. Specific molecular updates also described with almost each lesion to get confirmation from their differential diagnosis. This manuscript also highlights the changes in the nomenclature and addition of new entity, as adenoid ameloblastoma has been added in the category of benign odontogenic tumor. Also, surgical ciliated cyst has been Include in the cysts of jaws. Specific clinical, radiological, and histopathological features have been added with each entity which helps in quick and accurate diagnosis. The purpose of this review is to shed light on important changes in the new 2022 WHO odontogenic lesions classification, its difference from the 2017 WHO classification and a brief description on the essential diagnostic criteria and current molecular updates.