An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca2+ sensitivity

Abstract

Cytoplasmic Ca2+ is a pivotal regulator of IP3R activity. It is however controversial whether the [Ca2+] in the Endoplasmic Reticulum lumen also directly regulates channel function. We highlight a recent paper that demonstrates that luminal [Ca2+] potently inhibits IP3R activity. This regulation occurs indirectly by an interaction mediated through a binding partner, likely Annexin 1A.