An Innovative in Vivo Model for Bioassay-Guided Testing of Potential Antimicrobials.

Abstract

The use of in vivo models is critical in determining clinical relevance of potential chemotherapeutic molecules. Albeit mammals are of physiological relevance, the use of nonmammalian animals to investigate therapeutic efficacy of potential molecules at an initial stage of clinical research can complement in vitro studies. Here we suggest the use of a simple and inexpensive in vivo locust model in exploring the efficacy of novel chemotherapeutic molecules and/or large chemical libraries using high-throughput experimentation without legislative restrictions.