Abstract
This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4⋅0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.
Highlights
The investigated sample used α-CSH combined with autologous platelet gel that is obtained from the platelet-rich plasma (PRP) of New Zealand White (NZW) rabbits
The choice of bone graft material can affect the success of healing and bone regenThe choice of bone graft material can affect the success of healing and bone regenereration during osseointegration in areas experiencing bone loss, which is estimated by ation during osseointegration in areas experiencing bone loss, which is estimated by bone mineralsuch density (BMD)
Since BMD is relevant relevant to the Hounsfield unitwas (HU) value [41], in present study, BMD can be accessed via HU value, which to the HU value [41], in present study, BMD can be accessed via HU value, which is deis determined from the μ-CT imaging system
Summary
Some studies reported the technique with aim to increase primary implant stability and the initial bone-to-implant contact percentage in a poor bone density at maxillary region such as undersized implant preparation, osteotomy technique to condense bone around the implant, osteodistraction osteogenesis, and the ridge splitting technique. Those techniques seem to show an ineffectiveness to improve implant stability and bone density, and exhibit various complications post-surgery [10]. The various problems that arise when harvesting bone grafts from the donor site have resulted in the emergence of several bone grafts, which have been suggested as alternatives that can replace autogenous bone grafts in treating bone defects [1,4,6,11]
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