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Abstract
Objective: Depression is a common but serious mood disorder. The treatment cost is very high. The external auditory canal is used as a delivery platform and has overcome the dose dumping problem in the case of oral system. The current research work was to explore a novelistic route for targeting to the brain through ear by formulating nanosuspension using duloxetine as a model drug permitting better control over depression. Method: The concept was proved by preparing a nano-sized formulation of API i.e duloxetine and observed its pharmacological actions by sonication bath method. Bio-nano suspension was prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared viz 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, and 1:10. Results: The formulations were subjected to various evaluations, including pH, % transmittance, content uniformity, ex-vivo stability, release for over 36 hours. Different formulations of duloxetine out of which F1 (1:0.5) was found to be the best formulation having the r2 value of 0.9905 tT80: 22 hrs and the best fit model was found to be Higuchi matrix, and mechanism of transport was anomalous transport which was calculated by bits software. Conclusion: On the basis of the in-vitro results obtained it can be concluded that significant amount of drug reaches the brain via external acoustic meatus and so it is feasible to deliver Duloxetine by this novelistic route.
Highlights
Fibromatosis, known as desmoid tumor, is a rare disease
During staging work-up thorax tomography noted the involvement of pectoralis muscle and abdominal tomography revealed a similar-looking another lesion located on abdominal wall, right paraumblical region and trucut biopsy was the same as breast pathology (Fig 2)
Aggressive fibromatosis is a rare fibroblastic proliferation arising in musculoaponeurotic structure
Summary
Fibromatosis, known as desmoid tumor, is a rare disease. Breast fibromatosis is extremely rare and represents 4% of extra-abdominal desmoid tumors and 0,2% of all breast tumors. Aggressive fibromatosis (AF) arises from fibroblasts and it can be located at any part of the body. It is benign, it is locally aggressive. The cause of the AF is uncertain and can be related to trauma, hormonal factors or genetic association [1]. The AF of the breast generally occurs in implant-associated breast or a history of trauma (often surgical) [2,3,4,5,6,7,8]. We present a case of breast and abdominal AF in a woman to discuss optimal treatment management
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