Abstract
The goal of this investigation is the experimental and COSMO-RS theoretical determination of resveratrol (RSV) solubility in five choline chloride-based and five menthol-based natural deep eutectic solvents NADES. Choline chloride (ChCl) and menthol (ME) served as hydrogen bond acceptors (HBA). In contrast, as hydrogen bond donors (HBD), various natural organic compounds were used (urea, 1,2-propanediol, sorbitol, lactic acid, and ascorbic acid). By comparing experimental and theoretical results, it was proved that both results are in exceptional agreement. Obtained results show that the ChCl:1,2-propanediol system showed the highest solubilization potential at 211.05 ± 0.12 mg/mL. It was found that the RSV and NADES formulations show a high antioxidative effect, which is directly related to the solubility of RSV in NADES. Enhanced RSV solubility in NADES and consequently increased antioxidant activity and stability promote RSV formulations in NADES as functional food ingredients for design added value products.
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