Abstract
Biodegradable in situ thermo-sensitive hydrogels have potential applications in ophthalmic pharmaceutical preparations. Herein, a thermo-gel of PNICL-PEG-PNICL loaded with the natural compound epigallocatechin gallate (EGCG) used as a drug sustained release carrier was prepared by block bending strategy. Compared to mono polymers that cannot form a gel, mixing two block copolymers through a block blending strategy allows for the preparation of thermo-sensitive hydrogels. The temperature sensitive behavior of the system can be easily regulated by varying the blending ratios of the two polymers. Furthermore, the internal structure of the gel was investigated that indicated the system formed a permeable network through micelle aggregation. The biosafety of the system and its ability to sustainably release EGCG at 37 °C for 240 h were preliminarily demonstrated in vitro. This study has revealed the internal structural changes of block blending thermo-gels and tentatively justified their potential as drug carriers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
