An Injectable Oxidized Carboxymethyl Cellulose/Polyacryloyl Hydrazide Hydrogel via Schiff Base Reaction

Abstract

A series of injectable hydrogels was prepared by cross-linking oxidized carboxymethyl cellulose (oxi-CMC) with polyacryloyl hydrazide (PAH) via a Schiff base reaction under physiological conditions. The hydrogels exhibited superior performance such as appropriate rheology properties, high swelling ratio, and low degradation rate. In phosphate buffer solution (PBS, pH 7.4) at 37°C, the swelling ratio of the hydrogels ranged from 19 to 28 after 7 h, the degradation percentage of the oxi-CMC6/PAH3 hydrogel was ~47 % after 20 days. Using bovine serum albumin (BSA) as a model protein drug, the results of in vitro drug release studies demonstrated that the sustained release of BSA could be cooperatively controlled through drug diffusion and hydrogel degradation in PBS (pH 7.4) at 37°C, and the cumulative release percentage of BSA from a drug-loaded oxi-CMC6/PAH3 hydrogel was ~88 % after 8 days. The results signified that oxi-CMC6/PAH3 hydrogel could be potentially applied in the fields of drug delivery vehicles, tissue engineering, and cell encapsulation materials.