Abstract
Previous infrared studies of chloroform-soluble derivatives of the nucleic acid purines and pyrimidines have demonstrated considerable selectivity in hydrogen-bond formation. Hypoxanthine is an important minor base found in transfer RNA, often in the anti-codon position. This has prompted the extension of these studies to include the hydrogen-bonded association of a chloroform-soluble hypoxanthine derivative (2,3-benzylidine-5′-trityl-inosine (I)) with appropriate derivatives of guanine, cytosine, adenine, thymine and uracil. It was found that (I) associates strongly with the cytosine derivative, rather weakly with the adenine derivative, and scarcely at all with the other bases. Estimates have been made of the pair-wise association constants of the various bases in chloroform solution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
