An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene.

Xiaomeng Yang,Yong Liu,Yi Liu,Yue Li,Zhongtao Gai,Rui Dong,Ning Liu,Haiyan Zhang,Tiancheng Zhou

doi:10.1016/j.scr.2019.101635

An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene.

Xiaomeng Yang, Yong Liu + Show 7 more

Open Access

https://doi.org/10.1016/j.scr.2019.101635

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Journal: Stem cell research	Publication Date: Nov 2, 2019
Citations: 4	License type: cc-by-nc-nd

Affiliation: Qilu Hospital of Shandong University, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

#iPSC Line #Autism Spectrum Disorder + Show 8 more

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Abstract

Autism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder challenged in social reciprocity and restrictive repetitive behaviors. Here, we generated an induced pluripotent stem cell (iPSC) line SDQLCHi014-A from a patient with ASD and hyperactivity, carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene by reprogramming urine cells with non-integrating vectors. SDQLCHi014-A have shown full pluripotency, differentiation capacity and genetic stability. This iPSC line provides a valuable resource to study the molecular mechanisms underlying ASD.

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