Abstract
Abstract In a 3 year period, 105 patients with infertility and oligomenorrhea or amenorrhea were treated with clomiphene citrate and had adequate follow-up. Of these 105 women, 96 (91.4 per cent) ovulated with clomiphene and 40 (38.1 per cent) conceived. Twenty-eight women failed to ovulate at the maximum dosage (100 mg. per day × 5 days) recommended in the product brochure, but 19 of these patients ovulated at higher doses and 9 conceived. Eight (20 per cent) patients required longer than the recommended 3 months to conceive. In all, 14 (35 per cent) of the 40 women who conceived required more than the recommended dosage and/or needed more than 3 months of treatment. The over-all spontaneous abortion rate was 20.5 per cent. There was one multiple gestation. Ovarian cysts developed in 7 patients (6.7 per cent). Most of those who failed to conceive had additional infertility factors. When these multiple infertility factor patients are eliminated, the pregnancy rate in clomiphene-treated patients was 85.7 per cent.
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