Abstract
Summary Mechanisms and treatment of wear particle induced prosthetic aseptic loosening remain under investigation, as current animal models are not yet entirely favourable for researches because of individual differences or particle count differences. A new rat model of self-control continuous intramedullary infusion of ultra-high molecular weight polyethylene particles by osmotic pumps has been established in order to provide a more reliable model without the limitations mentioned above. Ten male Sprague–Dawley rats were used in this present study. A Kirschner wire and a hollow needle were placed into the medullary cavity of each femur. Two osmotic pumps containing different materials were implanted in the back of the rats, and the polyvinyl tubing connected with each side of the pumps was led subcutaneously to the knee joint and connected to the exposed needle. Radiological examination, histological analysis, tartrate-resistant acid phosphatase staining, immunohistochemistry, and biomechanical evaluation were performed 6 weeks after surgery. The mean optical density of the left femurs (control side) was 199.43 ± 62.36, whereas that of right femurs (treatment side) was 164.98 ± 26.47 (p
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