Abstract
目的 探讨创伤后应激障碍(PTSD)患者双侧海马活体MR波谱(MRS)的特点,为创伤后应激障碍的诊断和病因学机制提供线索.方法应用多体素活体MRS成像技术,对12例PTSD患者和12例正常对照者进行波谱分析,检测双侧海马的N-乙酰天门冬氨酸(NAA),肌酸(Cr)和含胆碱化合物(Cho)峰值,并进行统计学比较.结果PTSD患者左侧海马的NAA/Cr比值明显低于正常对照组(F=9.99,P=0.006),Cho/Cr比值差异无统计学意义(F=0.36,P=0.55);右侧海马的NAA/Cr比值、Cho/Cr比值差异均无统计学意义(F=1.44,P=0.25).性别之间的波谱差异比较无统计学意义(F=0.56,P=0.82);年龄、受教育时间、PTSD症状严重程度与左侧海马NAA/Cr比值的相关系数分别为0.47、0.35和0.18,差异无统计学意义(P＞0.05).结论PTSD患者左侧海马存在病理性变化,NAA/Cr比值低于正常人。
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