AN IN VITRO SCREENING TO COMPARE THE ANTI HEAD LICE ACTIVITY OF KSHEERAVIDARYADI TAILA PREPARED WITH NARIKELA TAILA AND KARANJA TAILA

Abstract

Pediculosis capitis, or head louse infestation, is a longstanding global concern, particularly prevalent in tropical and subtropical regions. Despite not posing a primary health threat, it remains a significant social problem, af-fecting millions worldwide. Existing treatments, including Permethrin, Malathion, and Lindane, often result in side effects such as irritation and swelling. While Ayurvedic texts mention references to head lice and their management, studies have yet to explore these aspects. This study investigates the efficacy of Ksheeravidaryadi Taila, a Taila yoga formulation, for treating head louse infestations. Two formulations, Sample-A (Narikela taila base) and Sample-B (Karanja taila base) were subjected to in-vitro screening, evaluating their effects on head lice movements, irritability, and vital signs over time. Methods: In-vitro screening involved the application of Sample-A and Sample-B on head lice, with comparative assessments against plain Narikela taila, Karanja taila, and distilled water. Observations were made on movements, irritability, and vital signs of the lice. Microscopic studies were conducted to analyze the effects further. Results: Sample B demonstrated a quicker and more po-tent action, inducing irritability and cessation of vital signs in head lice within 45 minutes. Sample A exhibited similar effects, albeit with milder intensity and a prolonged duration. Microscopic studies revealed no crucial signs in either sample, with bleeding observed in Sample B. Conclusion: The study underscores the potential efficacy of Ksheeravidaryadi Taila, particularly Sample B with Karanja taila base, which might be helpful for the treatment of head louse infestations. The formulation's alignment with Ayurvedic principles, including Tikta rasa and Krimihara attributes, coupled with faster drug action and higher saponification values, suggests its effective-ness.