Abstract
Ethanolic extracts of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes were taken for in vitro comparative studies on the anthelmintic activity against Pheritima posthuma. Different concentrations (25, 50, 100 mg/ml) of both the extracts were used for the activity. Varying albendazole concentrations (25, 50, 100 mg/ml) were used as a reference standard and normal saline (0.9% NaCl) was used for the control treatment. The results were expressed in terms of time in minutes to report the paralysis and time of death of the earthworms. The results obtained from the study indicate toward the anthelmintic activity, supporting folk use of both the plants when compared with the standard. The results also established that Z. zerumbet was a more potent candidature of as compared with H. spichatum.
Highlights
Ethanolic extracts of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes were taken for in vitro comparative studies on the anthelmintic activity against Pheritima posthuma
The survey published by Akhtar et al reported the use of H. spichatum as an anthelmintic in the Indian–Pakistan region.[3,4]
The plant was authenticated by the National Botanical Research Institute (NBRI), Lucknow
Summary
Ethanolic extracts of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes were taken for in vitro comparative studies on the anthelmintic activity against Pheritima posthuma. Rhizomes of Z. zerumbet have been reported for antipyretic and analgesic activities.[5] Somchit et al demonstrated the anti-inflammatory property of the ethanolic and aqueous extracts of Z. zerumbet.[6] Nadia et al reported that Zerumbone isolated from Z. zerumbet inhibited cancer cell growth of human ovarian and cervical origin.[7] Iqbal et al, performed a study on other plants of the Zingiberaceae and Cucurbutaceae families (Zingiber officinale, Curcurbita mexicana) in different anthelmintic models,[8] but H. spichatum and Z. zerumbet have not been evaluated scientifically for anthelmintic activity. In light of the above facts, this study has been designed to evaluate H. spichatum and Z. zerumbet for their anthelmintic activity against a Pheritima posthuma model
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