Abstract
Obesity is one of the significant risk factors commonly associated with lots of metabolic diseases penetrating in the younger age group population. In this study, we aimed to check the effectiveness of a carotenoid, β-cryptoxanthin, for reducing the adverse effect of obesity. The possible metabolic pathway of β-cryptoxanthin towards lowering obesity was hypothesized. Docking on different proteins involved in that pathway showed better binding affinity of β-cryptoxanthin with interactive proteins compared to the control. Stable and very strong binding of β-cryptoxanthin with PPAR-γ, PPAR-β/δ, and RAR-γ infer its effectiveness towards suppressing adipogenesis in Adipose tissue than other tissues. Furthermore, docking of β-cryptoxanthin with RAR showed better affinity than anti-obesity drugs for RAR induced adipogenesis suppression. Therefore, β-cryptoxanthin could be used as a potential natural ligand to treat obesity.
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