Abstract

AbstractA common statistical method for assessing bioequivalence of two formulations of a chemical substance is the symmetric confidence interval of WESTLAKE (1972). As mentioned by WEST‐LAKE (1981) and SCHUIRMAN (1981) a more powerful method consists of two one‐sided t‐tests. An (1‐α)‐confidence interval consistent with the two one‐sided t‐tests procedure is given by [min(α, 0), max (0, b)] where [a, b] is the conventional (1–2α)‐confidence interval of the t‐test. This “central” confidence interval is always a strict subset of the symmetric confidence interval and thus has more power in proving bioequivalence. The central confidence interval has properties comparable with those of the conventional one‐sided confidence intervals.

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