Abstract
In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess the impact of photobiomodulation (PBM) and arginine, individually and together, on the wound healing. In the pilot study, an excisional wound was made in each of 24 rats. There were 4 groups. Group 1 was the control group. In groups 2 and 3, wounds were topically treated with arginine ointments (ARG.) 2% and 5%, respectively. In group 4, arginine was injected (ARG. INJ.,i.p.). In the main phase, in 24 new rats, an excisional wound was made. There were 4 groups: group 5 served as the control. Wounds in group 6 were topically treated with ARG 2%. Wounds in group 7 were subjected to PBM. Wounds in group 8 were treated with PBM+ARG. 2%. On day 15, wound area measurement, wound strength, and stereological examination were performed. In the pilot study, we found that the ARG 2% ointment significantly decreased wound area than ARG. 5%, ARG. INJ. and control groups, and significantly increased wound strength compared to the control and ARG.5% groups. In the main phase, a significant decrease of wound area in all treatment regimens was induced. PBM + ARG. 2% and PBM treatment regimens significantly improved wound strength and almost all stereological parameters, compared to the control and ARG. 2% groups. PBM + ARG. 2% induced anti-inflammatory and angiogenic activities, and hastened the wound healing process in an excisional wound model in rats.
Highlights
About 234 million vital surgeries are undertaken annually [1]
All rats were arbitrarily distributed into 4 groups of six rats per group as follows: group 5 served as the control group
All rats were arbitrarily distributed into four groups of six rats per group as follows: group 5 served as the control group
Summary
About 234 million vital surgeries are undertaken annually [1]. Worldwide assessments recommend that no less than 7 million patients suffer from side-effects after surgery yearly, consists of at least 1 million dying [2]. Arginine is a basic amino acid that has many important functions in cell physiology. It is incorporated with protein production, but it is closely incorporated. Mostafavinia et al Laboratory Animal Research (2019) 35:28 described that both arginine and fish oils alone have benefits, but the mixture seems to be considerably more effective. This mixture has been revealed to influence results concerning skin injury repair, and could alter frequency and results in heart and vessels illnesses, DM, and other inflammatory diseases. The optimum mixtures of immunonutrients, scheduling of management, and the dosages required for finest outcomes need to be resolved in animal studies and clinical probes [7]
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