Abstract
An improved synthesis of a water-soluble deep-cavity cavitand (octa-acid, 1) is presented. Previously (Gibb, C.L.D.; Gibb, B.C. J. Am. Chem. Soc. 2004, 126, 11408–11409), we documented access to host 1 in eight (non-linear) steps starting from resorcinol; a synthesis that required four steps involving chromatographic purification. Here, we reveal a modified synthesis of host 1. Consisting of seven (non-linear) steps, this new synthesis involves only one chromatographic step, and avoids a minor impurity observed in the original approach. This improved synthesis is therefore useful for the laboratories that are investigating the properties of these types of host.
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