Abstract
AbstractThis study displays the facile and fluent electrochemical determination of uric acid (UA) through exceptional copper oxide nanostructures (CuO), as an effective sensing probe. The copper oxide nanostructures were fabricated via an aqueous chemical growth method using sodium hydroxide as a reducing agent, which massively hold hydroxide source. Copper oxide nanostructures showed astonishing electrocatalytic behavior in the detection of UA. Different characterization techniques such as XRD, FESEM, and EDS were exploited to determine crystalline nature, morphologies, and elemental composition of synthesized nanostructures. The cyclic voltammetry (CV) was subjected to investigate the electrochemical performance of UA using copper oxide nanostructures modified glassy carbon electrode CuO/GCE. The CV parameters were optimized at a scan rate of 50 mV/s with −0.7 to 0.9 potential range, and the UA response was investigated at 0.4 mV. PBS buffer of pH 7.4 was exploited as a supporting electrolyte. The linear dynamic range for UA was 0.001–351 mM with a very low limit of detection observed as 0.6 µM. The proposed sensor was successfully applied in urine samples for the detection of UA with improved sensitivity and selectivity.
Highlights
The exceptional chemical and physical properties of nanomaterials make them a prominent aspirant to design an appropriate and improved sensing device, mainly electrochemical and biosensors [1,2,3,4,5,6,7]
Copper oxide nanostructures were synthesized through the aqueous chemical growth method reported in [59]
A 0.1 M solution of NaOH was separately prepared in Milli-Q water of 100 mL capacity and properly mixed with 0.1 M copper acetate left on stirring until the solution become completely homogenized
Summary
The exceptional chemical and physical properties of nanomaterials make them a prominent aspirant to design an appropriate and improved sensing device, mainly electrochemical and biosensors [1,2,3,4,5,6,7]. E.g., metal and metal oxide nanomaterials, viz, NiO, SnO, ZnO, Co3O4, MgO, semiconductor nanoparticles, as well as carbon- and silicon-based nanosized materials have been efficiently employed in constructing the wide varieties of electrochemical and biosensors [8,9,10,11,12,13,14] Among these metal oxide nanoparticles, CuO nanostructures exhibited exception properties that enable them to be utilized in different applications such as chemical sensing devices, magnetic storage media, catalysis, sensors, semiconductors, etc. The determination of UA is very crucial in the diagnosis of various diseases [29,30,31,32] The methods such as spectroscopic [33], electroanalytical [34], capillary electrophoresis (CE) [35], chemiluminescence [36], and chromatographic techniques [37] are developed for the detection of UA. Scheme 1 shows the oxidation of uric acid at a modified electrode
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
