An improved method for the preparation of formyldeuteroporphyrins - Synthesis of biologically relevant porphyrins

Abstract

Pure 3 and 8 formyldeuteroporphyrin dimethylester isomers 3a,b have been prepared in high yield by formylation of readily accessible deuteroporphyrin dimethylester 1 with trimethyl orthoformate in trifluoroacetic acid and subsequent chromatographic separation of the mixture of isomers. The formyl-porphyrins can be transformed into synthetically and biologically useful derivatives.