Abstract
A convenient procedure has been developed for preparation of amine-substituted or monomethylamine-substituted alkyl/arylurea derivatives. The method comprises two steps—reaction of an alkyl/aryl amine with chlorocarbonylsulfenyl chloride in a non-polar solvent to produce an alkyl/arylcarbonylsulfenyl chloride, then reaction of this alkyl/arylcarbonylsulfenyl chloride with ammonia or monomethylamine in a two-phase reaction with a phase-transfer catalyst, to produce the corresponding alkyl/aryl-substituted urea. R 1 , R 2 : H, methyl, ethyl, propyl, butyl, benzyl, cyclohexyl; R 3 : H, methyl. A simple, one-pot, rapid, efficient, cost-effective, non-phosgene route for synthesis of alkyl/arylurea derivatives starting with the corresponding alkyl/aryl amine and chlorocarbonylsulfenyl chloride.
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