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Abstract
AbstractAlkyl‐, phenyl‐ and alkynyllithium reagents in combination with anhydrous cerium(III) chloride underwent addition reactions with 1,3‐dichloroacetone in a very efficient manner. The addition products are versatile precursors for 2‐substituted epichlorohydrins and glycidols. Fluconazole, a potent antifungal agent, was thus synthesized in 67% yield by addition of 1,3‐dichloroacetone to 2,4‐difluorophenyllithium in the presence of cerium(III) chloride, followed by substitution of the chlorine atoms with 1,2,4‐triazole.
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