Abstract
One of the crucial issues in the pharmacological field is developing new drug delivery systems. The main concern is to develop new methods for improving the drug delivery efficiencies such as low disruptions, precise control of the target of delivery and drug sustainability. Nowadays, there are many various methods for drug delivery systems. Carbon-based nanocarriers are a new efficient tool for translocating drug into the defined area or cells inside the body. These nanocarriers can be functionalized with proteins, peptides and used to transport their freight to cells or defined areas. Since functionalized carbon-based nanocarriers show low toxicity and high biocompatibility, they are used in many nanobiotechnology fields. In this study, different shapes of nanocarrier are investigated, and the suitable magnetic field, which is applied using MRI for the delivery of the nanocarrier, is proposed. In this research, based on the force required to cross the membrane and MD simulations, the optimal magnetic field profile is designed. This optimal magnetic force field is derived from the mathematical model of the system and magnetic particle dynamics inside the nanocarrier. The results of this paper illustrate the effects of the nanocarrier’s shapes on the percentage of success in crossing the membrane and the optimal required magnetic field.
Highlights
In the last few years, there has been a growing interest in discovering treatments for diseases by using magnetic cell membrane injection
The force needed to cross the membrane emerges through molecular dynamics simulation
By using the system identification method, a linear model has been fit to the data, and the relation between the forces and the velocities was expressed in the frequency domain
Summary
In the last few years, there has been a growing interest in discovering treatments for diseases by using magnetic cell membrane injection. The lipid bilayer is a fundamental component of all biological cells and provides their universal structure. It plays a critical role in the passage and blockage of substances into the cell [1]. Modern drug targeting delivery technologies have been proposed to overcome these cellular membranes. Regarding the significant advances in nanotechnology and biotechnology, nanoscale structures are extensively used in cellular biology. A widely-used method in this scope is exploiting nanocarriers such as carbon nanotubes (CNT) and nanocapsules, i.e., fullerene
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