An improved eco-friendly and solvent-free method for the one-pot synthesis of tetrahydropyrimidine derivatives via Biginelli condensation reaction using ZrO2/La2O3 catalysts

Abstract

The objective of the present study is focused on the facile synthesis of ZrO2/La2O3 catalyst and the catalytic performance was evaluated towards one-pot synthesis of tetrahydropyrimidne derivatives through Biginelli condensation reaction. The synthesized catalyst was characterized by using FTIR, XRD, BET, SEM, EDX and UV-DRS techniques. All catalysts perform better than the without catalyst based reactions, which is the formation of tetrahydropyrimidne derivatives (IVa-n) conversion averaging 85–95 % at 50 °C temperature and 3–40 min under identical reaction conditions. Also, it maintains good stability. The relative ease of reducing the catalyst plus its porous nature are responsible for its performance. All the products were characterized by comparing their physical and spectral data including FTIR, 1H NMR, and ESI-MS with those of authentic compounds reported in the literature.