Abstract
In this paper, the author has improved a model of electroporation of cell membrane in a biological system. The improved model elucidates that: the critical potential difference /spl Delta//spl psi//sub 0/ of electroporation is proportional to /sub g/spl tau/0/2//sup mL2/ and exp(/sub RT///sup /spl Delta/Ed/), where m, L and q are respectively mass, thickness and net charge of a membrane patch; /spl tau//sub 0/ is the critical time width of the externally imposed electric pulse; R is the gas constant; T is the absolute temperature of an electroporation system and /spl Delta/E/sub d/ (>0) is a thermodynamic energy of molecules in the cell membrane. /spl Delta/E/sub d/ is equal to an absolute value of a dragging energy bond of molecules in the interface between a patch and a cell. /spl Delta/E/sub d/ has been obtained and it is at a level of an absolute value of a hydrogen bond energy (5.44 kcal/mole) by fitting a set of experimental data.
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