Abstract
Histological and immunofluorescent techniques were used to examine changes in the cellular populations at the tumour-host interface in bovine ocular squamous cell carcinomas or their precursor lesions in a quantitative and semi-quantitative manner. In a number of cases the same techniques were used to study changes in the regional (parotid) lymph nodes. A total of 48 ocular and palpebral tumours, 38 parotid lymph nodes from the affected side, and 29 parotid lymph nodes from the contralateral side were examined. In normal bovine tissues in which the lesions of “cancer eye” usually appear, no immunoglobulin-containing (Ig) cells were observed on immunofluorescent examination. However, fluorescing cells were found in all precancerous and carcinomatous lesions. IgG-cells were overwhelmingly more numerous than IgM- or IgA-cells at every stage of neoplastic development and the greatest prevalence of IgG-cells seemed to occur in association with papillomas. In the stroma of tumours pyroninophils predominated over non-pyroninophilic mononuclear infiltrates. Immunofluorescent examination of parotid lymph nodes revealed no significant difference between the affected and contralateral sides. Histologically, however, the prevalence, size and mitotic activity of lymphoid follicles were each significantly greater in the parotid lymph node of the tumour affected side than in the contralateral parotid lymph node.
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