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Abstract
Abstract Rabbits were immunized with serial, intramuscular doses of low tissue culture passage“wild” and high passage “attenuated” strains of rubella virus. Rubella hemagglutination-inhibiting antibody was detected in animals immunized with two serial doses of 3 log10 TCD50/ml of low passage strains. However, no antibody was detected in animals immunized with 3 log10 TCD50/ml of the Cendehill vaccine strain of rubella virus. A reisolate virus from a person immunized with Cendehill rubella vaccine also had markedly reduced immunogenic properties in the rabbit. Experiments indicated that the Cendehill vaccine virus had a markedly decreased ability to infect rabbits by the intranasal route. The technique may be a useful marker test for this strain of rubella vaccine. The RA/27/3 and the HPV 77 rubella vaccine strains also had a reduced immunogenicity for rabbits but the results were too variable to be used as a marker test for these two strains.
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