Abstract
Absorbed rabbit antiserum with specific reactivity against human serous cystadenocarcinoma of the ovary was reacted with tissue extracts of various gynecologic cancers and malignant ovarian cyst fluids by the direct Ouchterlony double-diffusion and precipitin-inhibition techniques. In all specimens tested, serous cystadenocarcinomas and mucinous cystadenocarcinomas of the ovary were immunologically indistinguishable. Each contained at least two tumor-associated antigens. The major prcipitin band was shared by and appeared to be specific for serous and mucinous cystadenocarcinomas, whereas a faint precipitin band cross reacted with other tumors of the reproductive tract. An identical antigenic pattern was demonstrated for the cyst fluids of serous and mucinous cystadenocarcinomas. On the basis of these findings, the antigen(s) represented by the major precipitin band may be considered a common ovarian cystadenocarcinoma-associated one.
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