An Immunohistochemical Study to assess the Expression of Estrogen and Progesterone Receptor in Endometrial hyperplasia and Endometrial carcinoma compared to normal Endometrium: A Prospective Pathological Study

Abstract

Background: To compare the expression of ER, PR, and Her-2/neu in cases of endometrial hyperplasia and endometrial carcinoma within glands and stroma with normal endometrium. Methods: Samples of formalin-fixed, paraffin-embedded tissue of 62 patients coming to a tertiary care center were immunohistochemically studied for expression of ER and PR. Results: Steroid Hormone receptor levels of both ER and PR were overexpressed in endometrial hyperplasia and carcinoma compared to normal endometrium. However, same was significantly reduced in adenocarcinoma compared to simple hyperplasia and revealed a statistical significance with a p-value <0.05. Conclusions: Immunohistochemical expression of ER and PR should be evaluated in all cases of simple and atypical hyperplasia, and adenocarcinoma as their expression can facilitate a prognostic marker and can entail hormonal therapy in future for such cases.