An immunohistochemical study of the granulysin expression of 6 types of proven adverse cutaneous drug reaction

Marie Weinborn,François Truchetet,Annick Barbaud,Philippe Beurey,Bernard Cribier,Lucie Germain,Jean‐Luc Schmutz

doi:10.1186/2045-7022-4-s3-p3

Abstract

Background In Steven Johnson’s syndrome (SJS) and Toxic epidermal necrolysis (TEN), Chung et al. demonstrated that granulysin is the key cytotoxic molecule. But the specificity of granulysin in SJS-TEN is actually discussed. We studied the granulysin expression of 6 types of cutaneous adverse drug reaction (CADR) with a proven diagnosis (maculopapular exanthema (MPE), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), fixed drug eruption (FDE), SJS, TEN, acute generalized exanthematous pustulosis (AGEP)).

Highlights

In Steven Johnson’s syndrome (SJS) and Toxic epidermal necrolysis (TEN), Chung et al demonstrated that granulysin is the key cytotoxic molecule
We studied the granulysin expression of 6 types of cutaneous adverse drug reaction (CADR) with a proven diagnosis (maculopapular exanthema (MPE), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), fixed drug eruption (FDE), SJS, TEN, acute generalized exanthematous pustulosis (AGEP))
In DRESS cases, the expression is more intense and frequent (76%) (p=0.0002)

Summary

Introduction

An immunohistochemical study of the granulysin expression of 6 types of proven adverse cutaneous drug reaction Background In Steven Johnson’s syndrome (SJS) and Toxic epidermal necrolysis (TEN), Chung et al demonstrated that granulysin is the key cytotoxic molecule. The specificity of granulysin in SJS-TEN is discussed. We studied the granulysin expression of 6 types of cutaneous adverse drug reaction (CADR) with a proven diagnosis (maculopapular exanthema (MPE), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), fixed drug eruption (FDE), SJS, TEN, acute generalized exanthematous pustulosis (AGEP)).

Results

Conclusion