Abstract
AbstractTwenty‐one placentae were examined by light microscopic immunohistochemistry, scanning electron microscopy, transmission electron microscopy, and immunoelectron microscopy for the histogenesis of intervillous thrombus formation. Two possible mechanisms were investigated to explain the structural initiation of intervillous thrombus formation. Either the thrombus occurs precisely on the intravillous stromal fibril or the basal lamina, directly facing the intervillous space, and is derived from the degenerated trophoblastic epithelium in a similar fashion to conventional intravascular thrombus formation, or the thrombus is formed on the degenerated trophoblastic epithelium without any trophoblastic epithelial defects. The villous trophoblastic epithelium is, furthermore, thought to behave in the process of thrombus formation as the endothe‐lium in conventional intravascular thrombosis because the villous trophoblastic epithelium had the same stainability as the endothelium in ultrastructural localization of Factor VIII.
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