Abstract
Fixed polytene chromosome preparations have been stained by indirect immunofluorescence. Anti-H3 serum and anti-H4 serum cause very intense and highly specific staining of chromosomes. Anti-(H3–H4 complex) serum did not produce staining of chromosomes at a level above background. The results obtained in these staining experiments are in direct contrast to serological results obtained with soluble chromatin. It appears that a unique structure exists within the H3–H4 complex that is not present on the individual histone components. This structure is apparently destroyed or obscured by acetic acid fixation during the preparation of polytene chromosome spreads.
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