Abstract
Gel filtration of the total non-dialysable components in extracts of pigeon droppings permits resolution into non-specifically- and specifically-precipitating antigens. This latter mixture of glycoproteins – ‘B antigens’ – proved a valuable tool for the <i>in vitro</i> diagnosis of pigeon-breeder’s disease by double-diffusion-in-gel tests with suspected serum samples. Immunoelectrophoretic examination of precipitin-positive sera and B antigens showed the major reaction partner in the serum to reside in the <i>γ</i>-globulin region. Further analysis indicated that this <i>γ</i>-globulin might be one of the components of the C3 activator system. Experiments with extracts of isolated pigeon organs revealed detectable specific antigens in the muscular stomach, the gut, and even in the crop. The intestinal contents exhibited powerful protease activity, which persists in the pigeon excreta.
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