Abstract
The immunity induced by Trichinella spiralis infection in rats was studied by examining the changes in the histology of the local lymph nodes and spleen during an infection. Rats were orally infected with 1,000 T. spiralis larvae. Groups of rats were autopsied at regular intervals for 7 weeks. Mesenteric lymph nodes, spleen and mandibular lymph nodes were studied histologically with the aid of the immuno-fluorescence technique (detection of immunoglobulin), enzyme histochemistry (detection of acid phosphatase activity) and conventional histological techniques. In the tissues a rise in the number of immunoglobulin-containing cells could be detected at an early stage of the infection, indicating the induction of humoral immunity. Furthermore, the number of pyroninophilic blast cells in the thymusdependent areas increased and this was regarded as the morphological expression of the cell-mediated immunity. Although the humoral response was the more marked, this does not necessarily mean that this type of immunity is more important for protection of the host.
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