Year-end Sale % OFF 
Abstract
Abstract Innate lymphoid cells are recently identified cell population, which produces IL-5, IL-13, and GM-CSF in response to IL-33. These cells play an important role in anti-helminth immunity and allergic diseases. However, little is known about the role of innate lymphoid cells in tumor. We report in this study that sustained intratumoral expression of IL-33 establishes a high numbers of innate lymphoid cells secreting high levels of GM-CSF which are required for inhibition of tumor growth. GM-CSF strongly inhibits proliferation of mural cells (pericytes and smooth muscle cells), thereby preventing normal angiogenesis in tumor mass. Our results identify a previously unrecognized innate immune pathway involving innate lymphoid cells which mediated type-2 innate immunity leading to antitumor activity.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
